Regulation of triglyceride catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of triglyceride catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPLD1, AADAC, and PIK3CG, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPLD1 grouped by Regulation of triglyceride catabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GPLD1 →	-0.339	-1.383	.005	.003	3	8
LUNG_SCLC	AADAC →	-0.550	-1.761	.001	<.001	3	6
OVARY	PIK3CG →	-0.325	-1.186	.006	.008	3	5
SOFT_TISSUE	EPHA2 →	-0.198	-1.563	.002	<.001	3	5
BONE	FGF21 →	-0.280	-1.737	.007	<.001	3	5
BLOOD_Myeloma	MAT1A →	-0.238	-1.332	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPLD1 by Regulation of triglyceride catabolic process activity — PANCREAS

Explore this box plot interactively →