Regulation of triglyceride catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of triglyceride catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOBEC3C, ATXN7L3B, and ACAP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APOBEC3C grouped by Regulation of triglyceride catabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	APOBEC3C →	-1.661	-1.020	.001	.001	3	7
LUNG_NSCLC_LUAD	ATXN7L3B →	+0.548	+0.756	.002	.004	3	6
BLOOD_Lymphoma	ACAP1 →	-1.420	-1.995	.005	<.001	3	5
PANCREAS	WSB2 →	+0.658	+0.842	.002	.004	3	4
PANCREAS	LIN54 →	+0.645	+1.011	.002	.003	3	4
BLOOD_Leukemia	HMOX1 →	-1.364	-1.079	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APOBEC3C by Regulation of triglyceride catabolic process activity — CNS

Explore this box plot interactively →