Regulation of triglyceride catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of triglyceride catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UXS1, ITGA5, and RRAS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of triglyceride catabolic process activity versus UXS1 in BLOOD_Leukemia (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UXS1 →	+0.625	+0.643	.002	.001	3	5
LARGE_INTESTINE	ITGA5 →	+2.476	+0.393	.004	.003	3	5
LARGE_INTESTINE	RRAS →	+1.323	+0.341	.003	.003	3	4
BLOOD_Leukemia	YBX2 →	-1.784	-0.632	.001	.002	3	4
BLOOD_Leukemia	PXYLP1 →	-1.727	-0.890	<.001	.001	3	4
LARGE_INTESTINE	PRXL2B →	-1.010	-0.361	.004	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010896 vs UXS1 — BLOOD_Leukemia

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