Negative regulation of cholesterol storage

Across TCGA patient cohorts, RNA activity of the Negative regulation of cholesterol storage pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSD, SLC37A2, and TTC39B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cholesterol storage activity versus CTSD in GBM (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CTSD →	+0.564	+0.554	<.001	.004	3	4
GBM	SLC37A2 →	+0.844	+0.868	<.001	<.001	3	4
UCEC	TTC39B →	+0.708	+0.601	.001	.004	3	4
LSCC	FNBP1L →	-0.515	-0.258	<.001	.007	3	4
LSCC	NCF1B →	+0.345	+0.302	.004	.001	3	4
BRCA	SOX4 →	-0.519	-0.729	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010887 vs CTSD — GBM

Explore this scatter interactively →