Positive regulation of cholesterol efflux

Across TCGA cell cohorts, RNA activity of the Positive regulation of cholesterol efflux pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP2K6, CPED1, and LUC7L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cholesterol efflux activity versus MAP2K6 in LUNG_SCLC (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MAP2K6 →	-1.380	-1.008	.004	.002	3	5
BREAST	CPED1 →	+0.721	+0.848	.006	<.001	3	5
LIVER	LUC7L →	-0.476	-0.531	.005	.003	3	4
CNS	PLBD2 →	+0.932	+0.925	.001	.004	3	4
LUNG_SCLC	ADAMTS6 →	+0.825	+0.723	.009	.007	3	4
BREAST	CAV2 →	+3.639	+1.122	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010875 vs MAP2K6 — LUNG_SCLC

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