Regulation of cholesterol efflux

Across TCGA patient cohorts, RNA activity of the Regulation of cholesterol efflux pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRYL1, KIF2C, and PRPF40A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cholesterol efflux activity versus CRYL1 in UCEC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CRYL1 →	+0.504	+0.044	<.001	<.001	3	8
UCEC	KIF2C →	-0.835	-0.059	<.001	<.001	3	7
OV	PRPF40A →	-0.200	-0.044	<.001	.001	3	7
GBM	BUB1B_S543 →	-0.542	-0.038	<.001	<.001	3	7
BRCA	ALDH2 →	+0.718	+0.043	<.001	<.001	3	7
LUAD	NCAPG_S674 →	-1.052	-0.055	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010874 vs CRYL1 — UCEC

Explore this scatter interactively →