Regulation of cholesterol efflux

Across TCGA patient cohorts, RNA activity of the Regulation of cholesterol efflux pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFD, CTSD, and DIPK2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cholesterol efflux activity versus CFD in BRCA (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CFD →	+1.011	+0.382	<.001	.005	3	5
GBM	CTSD →	+0.541	+0.146	.005	.009	3	4
BRCA	DIPK2B →	+0.719	+0.579	<.001	.006	3	4
UCEC	PDE7B →	+0.977	+0.217	<.001	.001	3	4
GBM	FTL →	+0.613	+0.149	.005	.009	3	4
GBM	SLC7A8 →	+0.636	+0.194	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010874 vs CFD — BRCA

Explore this scatter interactively →