Regulation of cholesterol efflux

Across TCGA cell cohorts, RNA activity of the Regulation of cholesterol efflux pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAD, RPS15A, and GSN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cholesterol efflux activity versus BAD in LUNG_NSCLC_LUSC (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	BAD →	+1.036	+0.553	<.001	<.001	3	5
LIVER	RPS15A →	-0.766	-0.588	.007	<.001	3	5
LUNG_SCLC	GSN →	+1.968	+0.274	.001	<.001	3	5
LUNG_SCLC	NADSYN1 →	+0.907	+0.265	.005	.002	3	5
OESOPHAGUS	CCT8 →	-1.011	-0.402	<.001	<.001	3	4
LARGE_INTESTINE	ELK3 →	+1.579	+0.244	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010874 vs BAD — LUNG_NSCLC_LUSC

Explore this scatter interactively →