Negative regulation of triglyceride biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of triglyceride biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM124A, PLS3, and XG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of triglyceride biosynthetic process activity versus FAM124A in PDAC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FAM124A →	+0.323	+0.152	<.001	.002	3	4
BRCA	PLS3 →	-0.806	-0.748	<.001	<.001	3	4
BRCA	XG →	-0.618	-0.703	.006	.001	3	3
BRCA	ZNF273 →	-0.575	-0.672	<.001	.001	3	3
LUAD	RNU6-1233P →	-0.574	-0.124	.009	.002	3	3
OV	RPL26P29 →	+0.330	+0.251	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010868 vs FAM124A — PDAC

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