Negative regulation of triglyceride biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of triglyceride biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN14, TPPP, and MCOLN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPN14 grouped by Negative regulation of triglyceride biosynthetic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTPN14 →	-1.752	-1.545	.001	<.001	2	7
SKIN	TPPP →	+1.230	+1.132	.001	<.001	3	4
OESOPHAGUS	MCOLN2 →	+1.595	+1.454	<.001	.009	2	5
LUNG_NSCLC_LUAD	COTL1 →	-1.529	-0.889	<.001	<.001	3	4
LUNG_NSCLC_LUAD	ABCA1 →	-1.655	-0.868	<.001	.009	3	4
CNS	CSF1 →	-2.161	-0.970	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPN14 by Negative regulation of triglyceride biosynthetic process activity — LARGE_INTESTINE

Explore this box plot interactively →