Negative regulation of keratinocyte proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of keratinocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3CG, HCLS1, and RCSD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of keratinocyte proliferation activity versus PIK3CG in LSCC (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PIK3CG →	-0.728	-0.446	<.001	<.001	3	5
OV	HCLS1 →	-0.798	-0.625	<.001	.002	3	5
HNSC	RCSD1 →	-0.682	-0.613	.002	<.001	3	4
HNSC	VAV1 →	-0.665	-0.484	.008	.007	3	4
HNSC	ELMO1 →	-0.491	-0.482	.006	.004	3	4
HNSC	PPM1M →	-0.572	-0.592	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010839 vs PIK3CG — LSCC

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