Positive regulation of keratinocyte proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of keratinocyte proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNKS1BP1_S1073, PLIN3, and PARP4_S1722, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of keratinocyte proliferation activity versus TNKS1BP1_S1073 in CCRCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TNKS1BP1_S1073 →	+0.440	+0.122	<.001	<.001	3	6
CCRCC	PLIN3 →	+0.342	+0.101	<.001	<.001	3	6
OV	PARP4_S1722 →	+0.852	+0.078	<.001	<.001	3	6
CCRCC	GBF1_S314 →	+0.469	+0.120	<.001	<.001	3	6
LSCC	HCFC1 →	-0.112	-0.085	<.001	<.001	3	6
LSCC	RPRD2 →	-0.210	-0.081	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010838 vs TNKS1BP1_S1073 — CCRCC

Explore this scatter interactively →