Positive regulation of keratinocyte proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of keratinocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BATF3, SEPTIN14P21, and ZNF226, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of keratinocyte proliferation activity versus BATF3 in LSCC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BATF3 →	-0.306	-0.869	.007	.002	3	4
LUAD	SEPTIN14P21 →	+0.073	+0.651	<.001	<.001	3	3
GBM	ZNF226 →	-0.400	-0.651	.005	.004	3	3
GBM	JMJD1C →	-0.413	-0.820	.001	.001	3	3
HNSC	ZSCAN4 →	-0.358	-0.532	<.001	.002	3	3
GBM	FAM122A →	-0.295	-0.752	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010838 vs BATF3 — LSCC

Explore this scatter interactively →