Positive regulation of keratinocyte proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of keratinocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARCHF9, TMUB2, and SMIM3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MARCHF9 grouped by Positive regulation of keratinocyte proliferation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MARCHF9 →	-1.632	-1.756	.007	<.001	3	4
CNS	TMUB2 →	-0.661	-0.968	<.001	.001	3	4
BREAST	SMIM3 →	-1.066	-0.705	.007	.008	3	4
LARGE_INTESTINE	LENG1 →	+0.340	+0.765	.008	.004	3	4
LUNG_NSCLC_LUSC	SMIM29 →	-0.935	-1.408	.003	.004	3	4
LUNG_NSCLC_LUSC	PIGV →	-0.985	-1.338	.004	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MARCHF9 by Positive regulation of keratinocyte proliferation activity — URINARY_TRACT

Explore this box plot interactively →