Regulation of keratinocyte proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of keratinocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAF3IP2, GBP3, and VDR, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of keratinocyte proliferation activity versus TRAF3IP2 in SOFT_TISSUE (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TRAF3IP2 →	+2.752	+0.136	<.001	<.001	3	12
BONE	GBP3 →	+2.726	+0.132	<.001	<.001	3	11
STOMACH	VDR →	+2.174	+0.135	<.001	<.001	3	10
URINARY_TRACT	FBXO43 →	-1.524	-0.142	<.001	<.001	3	10
STOMACH	C1orf116 →	+3.073	+0.138	<.001	<.001	3	10
URINARY_TRACT	GJB3 →	+3.388	+0.124	.003	.009	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010837 vs TRAF3IP2 — SOFT_TISSUE

Explore this scatter interactively →