Regulation of protein ADP-ribosylation

Across TCGA patient cohorts, RNA activity of the Regulation of protein ADP-ribosylation pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSANTD2, FNBP4, and MAP3K12, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein ADP-ribosylation activity versus MSANTD2 in UVM (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	MSANTD2 →	+1.018	+0.063	<.001	<.001	3	28
UVM	FNBP4 →	+1.320	+0.059	<.001	<.001	3	27
UVM	MAP3K12 →	+0.897	+0.046	.005	<.001	3	27
UVM	EP400P1 →	+0.716	+0.060	<.001	<.001	3	27
THYM	NFYC-AS1 →	+1.102	+0.075	<.001	<.001	3	27
UVM	RBM6 →	+1.047	+0.050	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010835 vs MSANTD2 — UVM

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