Regulation of protein ADP-ribosylation

Across TCGA patient cohorts, RNA activity of the Regulation of protein ADP-ribosylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLPX, PPL_S1670, and SELENOO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein ADP-ribosylation activity versus CLPX in HNSC (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CLPX →	-0.223	-0.084	.003	.002	3	4
COAD	PPL_S1670 →	-1.300	-0.080	<.001	.008	3	4
CCRCC	SELENOO →	-0.202	-0.045	.001	<.001	3	4
GBM	TTLL12 →	-0.313	-0.062	<.001	<.001	3	4
LSCC	LAD1 →	-0.672	-0.072	<.001	<.001	3	4
LUAD	PKP3_S314 →	-0.400	-0.035	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010835 vs CLPX — HNSC

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