Regulation of protein ADP-ribosylation

Across TCGA patient cohorts, RNA activity of the Regulation of protein ADP-ribosylation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRRM5, USP21, and HMGB3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein ADP-ribosylation activity versus SRRM5 in HNSC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SRRM5 →	+0.505	+0.408	<.001	<.001	3	6
BRCA	USP21 →	+0.346	+0.138	.001	.005	3	5
HNSC	HMGB3 →	+0.772	+0.476	<.001	<.001	3	4
GBM	GINS1 →	+0.938	+0.724	<.001	<.001	3	4
GBM	MYBL2 →	+1.223	+0.884	<.001	<.001	3	4
GBM	MCM4 →	+0.547	+0.676	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010835 vs SRRM5 — HNSC

Explore this scatter interactively →