Regulation of protein ADP-ribosylation

Across TCGA cell cohorts, RNA activity of the Regulation of protein ADP-ribosylation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C4orf3, SAP30, and MT-ND3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein ADP-ribosylation activity versus C4orf3 in OVARY (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C4orf3 →	-1.338	-0.231	.004	<.001	3	6
OVARY	SAP30 →	-0.834	-0.173	.005	.003	3	6
OVARY	MT-ND3 →	+0.803	+0.214	.003	.002	3	5
URINARY_TRACT	OXSR1 →	-0.645	-0.265	<.001	.006	3	5
URINARY_TRACT	S100A2 →	+7.367	+0.371	<.001	<.001	3	5
OESOPHAGUS	GNAI2 →	-0.963	-0.174	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010835 vs C4orf3 — OVARY

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