Telomere maintenance via telomere lengthening

Across TCGA patient cohorts, RNA activity of the Telomere maintenance via telomere lengthening pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX17, TNRC6B, and CEP128, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance via telomere lengthening activity versus DDX17 in UVM (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	DDX17 →	+1.424	+0.040	<.001	<.001	3	34
DLBC	TNRC6B →	+1.009	+0.067	<.001	<.001	3	34
THYM	CEP128 →	+1.374	+0.034	<.001	<.001	3	34
DLBC	ADNP →	+1.248	+0.066	<.001	<.001	3	34
UVM	RNMT →	+1.299	+0.038	<.001	<.001	3	34
UVM	XIAP →	+1.658	+0.041	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010833 vs DDX17 — UVM

Explore this scatter interactively →