Telomere maintenance via telomere lengthening

Across TCGA patient cohorts, RNA activity of the Telomere maintenance via telomere lengthening pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC1A, SMC3, and ADNP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance via telomere lengthening activity versus SMC1A in LSCC (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC1A →	+0.343	+0.048	<.001	<.001	3	7
HNSC	SMC3 →	+0.271	+0.069	<.001	<.001	3	7
LSCC	ADNP →	+0.394	+0.043	.002	.002	3	7
HNSC	HCFC1 →	+0.201	+0.066	.003	.007	3	7
HNSC	NCOA5 →	+0.255	+0.065	<.001	.003	3	7
LSCC	POGZ →	+0.392	+0.047	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010833 vs SMC1A — LSCC

Explore this scatter interactively →