Telomere maintenance via telomere lengthening

Across TCGA cell cohorts, RNA activity of the Telomere maintenance via telomere lengthening pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECM1, TFDP2, and MVP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomere maintenance via telomere lengthening activity versus ECM1 in BREAST (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ECM1 →	-2.027	-0.133	.002	.003	2	6
OVARY	TFDP2 →	+0.850	+0.220	<.001	.001	3	5
BLOOD_Lymphoma	MVP →	-2.460	-0.185	.005	.002	2	6
CNS	CTNNA1 →	-0.385	-0.112	.004	.008	3	4
URINARY_TRACT	FBXO21 →	+0.490	+0.324	<.001	<.001	3	4
URINARY_TRACT	PRDM10 →	+0.454	+0.256	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010833 vs ECM1 — BREAST

Explore this scatter interactively →