Negative regulation of myotube differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of myotube differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM119, CCN3, and ZNF366, each associated with the pathway in up to 25 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of myotube differentiation activity versus TMEM119 in UVM (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	TMEM119 →	+2.381	+0.072	<.001	<.001	3	25
PCPG	CCN3 →	+2.627	+0.069	<.001	<.001	3	24
TGCT	ZNF366 →	+0.592	+0.036	<.001	<.001	3	23
MESO	CILP →	+1.716	+0.058	.001	<.001	2	23
TGCT	ENG →	+0.935	+0.052	<.001	<.001	3	21
UVM	CXCL12 →	+1.236	+0.059	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010832 vs TMEM119 — UVM

Explore this scatter interactively →