Negative regulation of myotube differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of myotube differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BRIP1_T989, THSD4_S557, and COL15A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of myotube differentiation activity versus BRIP1_T989 in UCEC (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BRIP1_T989 →	-0.963	-0.071	<.001	<.001	3	6
BRCA	THSD4_S557 →	+0.781	+0.041	.007	.004	3	5
UCEC	COL15A1 →	+0.610	+0.072	.001	.003	3	5
PDAC	AKAP12_S660 →	+0.448	+0.050	.001	<.001	3	5
OV	CBX1 →	+0.336	+0.056	.001	<.001	3	5
GBM	CLIC2 →	+0.701	+0.058	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010832 vs BRIP1_T989 — UCEC

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