Negative regulation of myotube differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of myotube differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF652, DNAH14, and RHOG2P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of myotube differentiation activity versus ZNF652 in HNSC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF652 →	+0.561	+0.172	<.001	.003	3	4
LSCC	DNAH14 →	+0.620	+0.126	<.001	.004	3	3
LSCC	RHOG2P →	+0.330	+0.134	.004	.002	3	3
LSCC	MRPS9-AS2 →	+0.283	+0.170	.007	.006	3	3
LSCC	RPSAP13 →	+0.577	+0.170	<.001	.002	3	3
UCEC	CXCL12 →	+1.019	+0.540	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010832 vs ZNF652 — HNSC

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