Negative regulation of myotube differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of myotube differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNAPIN, AFTPH, and RAB5B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNAPIN grouped by Negative regulation of myotube differentiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SNAPIN →	+0.614	+0.981	.009	.007	3	5
OESOPHAGUS	AFTPH →	+0.660	+0.960	<.001	.009	3	4
OVARY	RAB5B →	+0.887	+1.517	<.001	<.001	3	4
SOFT_TISSUE	NEMF →	-0.929	-1.756	.002	.004	3	4
OVARY	C8orf58 →	-1.017	-1.132	.007	.007	3	4
SOFT_TISSUE	ACTA2 →	-3.729	-1.547	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNAPIN by Negative regulation of myotube differentiation activity — BLOOD_Leukemia

Explore this box plot interactively →