Negative regulation of myotube differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of myotube differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLDIP3, CDADC1, and SYT17, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of myotube differentiation activity versus POLDIP3 in LARGE_INTESTINE (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	POLDIP3 →	-1.063	-2.186	.004	<.001	3	1
LARGE_INTESTINE	CDADC1 →	-0.749	-2.235	.003	<.001	3	1
LARGE_INTESTINE	SYT17 →	-2.506	-2.165	.001	<.001	3	1
LARGE_INTESTINE	CCP110 →	-1.330	-2.069	.008	.001	3	1
LARGE_INTESTINE	HOMER2 →	-2.706	-2.072	.005	<.001	3	1
LARGE_INTESTINE	MAP4K1 →	-0.567	-2.142	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010832 vs POLDIP3 — LARGE_INTESTINE

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