Positive regulation of myotube differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of myotube differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NNMT, FCGR2A, and LIMS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myotube differentiation activity versus NNMT in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NNMT →	+1.625	+0.912	<.001	<.001	3	4
GBM	FCGR2A →	+0.908	+0.810	<.001	<.001	3	4
GBM	LIMS1 →	+0.529	+0.740	<.001	<.001	3	4
GBM	CXCL8 →	+1.889	+0.818	<.001	<.001	3	3
PDAC	MT1E →	+0.518	+0.343	.001	.006	3	3
GBM	FPR2 →	+1.011	+0.734	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010831 vs NNMT — GBM

Explore this scatter interactively →