Positive regulation of myotube differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of myotube differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTF2, RASGEF1A, and ISY1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TTF2 grouped by Positive regulation of myotube differentiation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TTF2 →	+0.692	+1.200	.004	.003	3	4
LUNG_SCLC	RASGEF1A →	-2.345	-1.392	<.001	.001	3	4
LUNG_SCLC	ISY1 →	+1.018	+1.650	<.001	<.001	3	4
LUNG_SCLC	KIZ →	+0.933	+1.098	<.001	.002	3	4
LUNG_NSCLC_LUAD	CDK1 →	+0.536	+0.707	.001	.002	3	4
BREAST	GDF15 →	-2.263	-0.820	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TTF2 by Positive regulation of myotube differentiation activity — LUNG_SCLC

Explore this box plot interactively →