Positive regulation of myotube differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of myotube differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP14, CD276, and COL6A1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myotube differentiation activity versus MMP14 in BREAST (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MMP14 →	+3.947	+1.750	<.001	<.001	3	11
OESOPHAGUS	CD276 →	+1.646	+1.938	.004	.002	3	5
CNS	COL6A1 →	+2.289	+1.027	.001	.006	3	5
PANCREAS	PLXNA1 →	+1.956	+1.464	.001	.001	3	4
PANCREAS	SULF2 →	+6.302	+2.023	<.001	<.001	3	4
LARGE_INTESTINE	ALPP →	+2.368	+0.399	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010831 vs MMP14 — BREAST

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