Regulation of myotube differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of myotube differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TACC1, ADH1B, and DCLK1_S720, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myotube differentiation activity versus TACC1 in PDAC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TACC1 →	+0.208	+0.039	<.001	.004	3	4
PDAC	ADH1B →	+0.939	+0.043	<.001	<.001	3	4
PDAC	DCLK1_S720 →	+0.716	+0.045	<.001	<.001	3	4
UCEC	MAP1A_S2106 →	+0.721	+0.055	.001	.004	3	4
PDAC	MLYCD →	+0.183	+0.036	.001	.002	3	4
LSCC	CENPU_S139 →	-0.420	-0.035	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010830 vs TACC1 — PDAC

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