Regulation of myotube differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of myotube differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SWAP70, DUSP6, and HPS5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SWAP70 grouped by Regulation of myotube differentiation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SWAP70 →	-1.715	-0.272	.007	.001	3	5
STOMACH	DUSP6 →	-2.122	-0.134	.002	.003	3	4
OESOPHAGUS	HPS5 →	+0.824	+0.169	<.001	.002	3	4
LUNG_SCLC	DENND2A →	+2.663	+0.269	<.001	.001	3	4
SOFT_TISSUE	REEP1 →	+1.900	+0.702	<.001	.007	3	4
URINARY_TRACT	CBX7 →	-1.720	-0.257	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SWAP70 by Regulation of myotube differentiation activity — LUNG_SCLC

Explore this box plot interactively →