Regulation of myotube differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of myotube differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALOX5, REM2, and OXGR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALOX5 grouped by Regulation of myotube differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ALOX5 →	-0.134	-0.847	<.001	<.001	3	3
BREAST	REM2 →	+0.120	+0.758	.002	.009	3	3
BREAST	OXGR1 →	-0.208	-0.893	.004	.002	3	3
BREAST	ITPR3 →	-0.103	-0.897	.007	<.001	3	3
LUNG_NSCLC_LUSC	ILKAP →	+0.296	+1.674	.003	<.001	3	3
BLOOD_Lymphoma	PAQR3 →	-0.250	-0.242	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALOX5 by Regulation of myotube differentiation activity — BREAST

Explore this box plot interactively →