Regulation of glucose transmembrane transport

Across TCGA cell cohorts, RNA activity of the Regulation of glucose transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELP2, TTC12, and BTBD11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELP2 grouped by Regulation of glucose transmembrane transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ELP2 →	-0.862	-0.861	.009	.009	3	4
URINARY_TRACT	TTC12 →	-1.014	-1.367	.006	.007	3	4
BLOOD_Leukemia	BTBD11 →	-0.826	-0.430	.001	.009	3	3
PANCREAS	C19orf73 →	+0.450	+0.839	.001	<.001	3	3
BLOOD_Myeloma	NSMCE3 →	+1.405	+1.662	<.001	<.001	3	3
OVARY	OXNAD1 →	-0.598	-0.819	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELP2 by Regulation of glucose transmembrane transport activity — LUNG_SCLC

Explore this box plot interactively →