Regulation of glucose transmembrane transport

Across TCGA cell cohorts, RNA activity of the Regulation of glucose transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP93, GINS3, and LRR1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucose transmembrane transport activity versus NUP93 in BLOOD_Leukemia (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NUP93 →	-0.527	-0.072	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	GINS3 →	-0.923	-0.053	.008	.008	2	12
KIDNEY	LRR1 →	-0.955	-0.084	<.001	.001	3	10
KIDNEY	POLE2 →	-0.965	-0.085	.004	.002	2	10
KIDNEY	AUNIP →	-0.905	-0.074	.003	.009	3	9
KIDNEY	SRSF7 →	-0.784	-0.097	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010827 vs NUP93 — BLOOD_Leukemia

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