Regulation of glucose transmembrane transport

Across TCGA cell cohorts, RNA activity of the Regulation of glucose transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAB39, PEA15, and JPH2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glucose transmembrane transport activity versus CAB39 in LUNG_NSCLC_LUAD (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CAB39 →	+1.049	+0.757	<.001	<.001	3	6
OVARY	PEA15 →	+1.752	+1.175	.002	<.001	3	6
SOFT_TISSUE	JPH2 →	+2.822	+0.765	.001	.009	3	6
CNS	UQCRH →	-0.781	-0.317	<.001	<.001	2	6
STOMACH	ZSWIM3 →	+0.688	+0.630	.008	.007	3	5
SOFT_TISSUE	PHLDB2 →	+4.900	+0.660	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010827 vs CAB39 — LUNG_NSCLC_LUAD

Explore this scatter interactively →