Negative regulation of centrosome duplication

Across TCGA patient cohorts, RNA activity of the Negative regulation of centrosome duplication pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, PCNA, and LIG1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of centrosome duplication activity versus RFC2 in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC2 →	+0.431	+0.062	<.001	<.001	3	8
GBM	PCNA →	+0.500	+0.071	<.001	<.001	3	8
UCEC	LIG1 →	+0.404	+0.062	<.001	.001	3	8
UCEC	STIM1 →	-0.422	-0.064	<.001	<.001	3	7
LUAD	TIMELESS_S1173 →	+0.591	+0.047	<.001	<.001	3	7
LSCC	ERCC1 →	+0.207	+0.061	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010826 vs RFC2 — GBM

Explore this scatter interactively →