Negative regulation of centrosome duplication

Across TCGA cell cohorts, RNA activity of the Negative regulation of centrosome duplication pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF519, SLC48A1, and SMAD5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF519 grouped by Negative regulation of centrosome duplication-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZNF519 →	-1.407	-0.338	<.001	.001	3	4
SOFT_TISSUE	SLC48A1 →	+2.741	+0.433	<.001	.001	3	4
URINARY_TRACT	SMAD5 →	+0.675	+0.360	.002	.004	3	4
SKIN	SETD9 →	-1.046	-0.240	.002	.005	3	3
BREAST	RUNX1 →	+1.507	+0.310	<.001	<.001	3	3
BREAST	EFR3A →	+0.752	+0.340	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF519 by Negative regulation of centrosome duplication activity — STOMACH

Explore this box plot interactively →