Obsolete positive regulation of mitochondrion organization

pathway activity — cross-omics
GO:0010822Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Obsolete positive regulation of mitochondrion organization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SULF1, THBS2, and COL1A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADSULF1 →+0.679+0.035<.001<.00136
COADTHBS2 →+0.932+0.021<.001<.00136
COADCOL1A1 →+0.750+0.027<.001<.00136
COADFAP →+0.891+0.034<.001<.00136
GBMSEH1L →-0.155-0.030<.001<.00136
BRCARPL5 →-0.248-0.019<.001.00826
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration