Obsolete positive regulation of mitochondrion organization

pathway activity — cross-omics
GO:0010822Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Obsolete positive regulation of mitochondrion organization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOX18, RNU7-151P, and ZNF385D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVSOX18 →-0.955-0.192.001<.00134
COADRNU7-151P →-0.700-0.124.006.00234
CCRCCZNF385D →-0.521-0.184.003.00134
HNSCPES1 →+0.644+0.095.003.00333
HNSCHMOX2 →+0.713+0.102.001.00133
HNSCEBF3 →-0.590-0.147<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration