Regulation of mitochondrion organization

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrion organization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SETD6, DDX54, and NDUFAF6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SETD6 grouped by Regulation of mitochondrion organization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SETD6 →	+0.988	+0.204	<.001	<.001	3	4
BLOOD_Myeloma	DDX54 →	+0.956	+0.284	.002	<.001	3	4
STOMACH	NDUFAF6 →	+0.746	+0.186	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MYORG →	+1.160	+0.146	.009	.007	3	4
OVARY	FARS2 →	-0.570	-0.272	<.001	.001	3	4
LUNG_SCLC	DDX55 →	+0.699	+0.266	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SETD6 by Regulation of mitochondrion organization activity — PANCREAS

Explore this box plot interactively →