Regulation of mitochondrion organization

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrion organization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MX1, IFI27, and APOL1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrion organization activity versus MX1 in OVARY (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MX1 →	+2.642	+0.068	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	IFI27 →	+5.006	+0.069	<.001	.002	3	13
PANCREAS	APOL1 →	+2.486	+0.077	.001	<.001	3	13
BONE	HERC6 →	+1.769	+0.100	<.001	<.001	3	13
STOMACH	HELZ2 →	+1.958	+0.094	<.001	<.001	3	13
SKIN	EPHB2 →	+1.567	+0.060	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010821 vs MX1 — OVARY

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