Regulation of T cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Regulation of T cell chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT1, GBP4, and TRPV2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell chemotaxis activity versus STAT1 in BRCA (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STAT1 →	+0.694	+0.055	<.001	<.001	3	10
BRCA	GBP4 →	+0.633	+0.048	<.001	<.001	3	9
UCEC	TRPV2 →	+0.590	+0.112	.001	.002	3	9
OV	CD53 →	+0.609	+0.052	<.001	<.001	3	9
BRCA	CYBB →	+0.756	+0.052	<.001	<.001	3	9
CCRCC	DEF6 →	+0.406	+0.049	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010819 vs STAT1 — BRCA

Explore this scatter interactively →