Regulation of T cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Regulation of T cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RN7SKP259, RPL31P30, and LINC00596, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell chemotaxis activity versus RN7SKP259 in PDAC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RN7SKP259 →	-0.211	-0.444	<.001	<.001	3	3
PDAC	RPL31P30 →	-0.160	-0.352	.004	.004	3	3
OV	LINC00596 →	-0.191	-0.290	<.001	.006	3	3
BRCA	APOBEC3C →	+0.485	+0.222	.004	<.001	3	3
GBM	LINC02115 →	-0.495	-0.314	.002	.008	3	3
LUAD	FRRS1 →	+0.320	+0.431	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010819 vs RN7SKP259 — PDAC

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