Regulation of T cell chemotaxis

Across TCGA patient cohorts, RNA activity of the Regulation of T cell chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADAM17_T735, RPS6KB1_T444, and CCDC86_S80, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell chemotaxis activity versus ADAM17_T735 in BRCA (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ADAM17_T735 →	+0.632	+0.228	<.001	<.001	3	4
COAD	RPS6KB1_T444 →	+0.558	+0.494	<.001	<.001	3	3
OV	CCDC86_S80 →	-1.395	-0.341	<.001	<.001	3	3
OV	DENND1C_S480 →	+1.106	+0.507	<.001	.002	3	3
COAD	NCOR1_S1977 →	-0.295	-0.268	<.001	<.001	3	3
BRCA	RNF20 →	-0.172	-0.237	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010819 vs ADAM17_T735 — BRCA

Explore this scatter interactively →