Regulation of T cell chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of T cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PERP, NRG1, and HNRNPUL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of T cell chemotaxis activity versus PERP in SKIN (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PERP →	-1.189	-0.647	.006	.006	3	4
PANCREAS	NRG1 →	-3.357	-0.756	<.001	.003	3	4
SOFT_TISSUE	HNRNPUL2 →	+0.612	+1.204	.003	.002	3	4
SOFT_TISSUE	GGPS1 →	-0.672	-1.296	.001	<.001	3	4
SKIN	EEF1AKMT2 →	-0.489	-0.760	.003	.002	3	3
BLOOD_Myeloma	UBQLN1 →	-0.961	-1.243	.004	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010819 vs PERP — SKIN

Explore this scatter interactively →