T cell chemotaxis

Across TCGA patient cohorts, RNA activity of the T cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFL2, TMEM97, and PRRX1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell chemotaxis activity versus IGFL2 in PDAC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	IGFL2 →	+0.902	+0.364	<.001	<.001	3	6
LUAD	TMEM97 →	-0.721	-0.210	<.001	.002	3	5
PDAC	PRRX1 →	+0.651	+0.355	.001	.001	3	5
GBM	EMP3 →	+0.685	+0.523	.001	.004	2	6
LUAD	ITGA3 →	+0.819	+0.214	.002	.005	2	6
PDAC	MXRA8 →	+0.535	+0.404	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010818 vs IGFL2 — PDAC

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