T cell chemotaxis

Across TCGA cell cohorts, RNA activity of the T cell chemotaxis pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLITRK2, ZNF18, and BNIP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLITRK2 grouped by T cell chemotaxis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLITRK2 →	+0.117	+0.164	.006	.003	3	5
UPPER_AERODIGESTIVE_TRACT	ZNF18 →	+0.125	+0.356	.009	<.001	3	4
SKIN	BNIP2 →	+0.196	+0.142	<.001	<.001	3	4
OVARY	RFX5 →	-0.215	-0.245	<.001	.002	3	4
LARGE_INTESTINE	LRRC31 →	-0.232	-0.347	.004	.003	3	4
LUNG_NSCLC_LUAD	TUBG1 →	+0.197	+0.174	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLITRK2 by T cell chemotaxis activity — SKIN

Explore this box plot interactively →