T cell chemotaxis

Across TCGA cell cohorts, RNA activity of the T cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCL16, ELF3, and SLC12A2, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell chemotaxis activity versus CXCL16 in LARGE_INTESTINE (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CXCL16 →	+2.452	+0.293	<.001	<.001	3	13
STOMACH	ELF3 →	+3.141	+0.446	<.001	<.001	3	11
STOMACH	SLC12A2 →	+2.140	+0.486	<.001	<.001	3	10
STOMACH	ZMYND15 →	+1.054	+0.573	<.001	.002	3	9
STOMACH	TC2N →	+2.706	+0.478	<.001	<.001	3	9
OESOPHAGUS	STARD10 →	+2.278	+0.273	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010818 vs CXCL16 — LARGE_INTESTINE

Explore this scatter interactively →