T cell chemotaxis

Across TCGA cell cohorts, RNA activity of the T cell chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A4, BCL7A, and PLEC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell chemotaxis activity versus SLC22A4 in SOFT_TISSUE (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC22A4 →	+2.194	+0.212	<.001	.001	3	5
SKIN	BCL7A →	-1.011	-0.184	.007	<.001	3	5
SOFT_TISSUE	PLEC →	+1.574	+0.212	.001	.001	3	5
PANCREAS	NAT8L →	-1.918	-0.328	.002	<.001	3	4
PANCREAS	DPP4 →	+2.415	+0.170	.005	.006	2	5
BREAST	SLC12A2 →	+1.840	+0.267	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010818 vs SLC22A4 — SOFT_TISSUE

Explore this scatter interactively →